Compounds and Methods for the Detection of Hydrogen Peroxide
- Research Tools and Methods
Background and Market Opportunity
- Hydrogen peroxide plays a crucial role in oxidative stress and signal transduction in organisms.
- In order to investigate the reaction mechanisms of hydrogen peroxide, analytical approaches using chemiluminescence and fluorescence probes have been developed to detect its intracellular generation.
- There are commercially available fluorescence probes for hydrogen peroxide detection analysis, for example, Amplex Red reagent has been used to detect the release of hydrogen peroxide from activated human leukocytes.
- However, many commercially available fluorescence probes suffer from drawbacks, such as slow response time and sensitivity, making tracking hydrogen peroxide in situ difficult.
Technology Overview and Key Advantages
- This invention employs a new chemistry, to provide an ultra-efficient and novel mechanism for H2O2 detection, thus escalating the sensitivity and selectivity toward H2O2 and avoiding the interference from cellular ROS/RNS.
- Highly selective in situ, in vivo, and in vitro.
- High sensitivity and selectivity towards hydrogen peroxide.
- Can avoid the interference from cellular ROS/RNS.
- Highly robust performance in multiple cell types.
Potential Product and Applications
- Detection methods for drug screening, cancer screening and disease diagnosis.
- Investigate tumor initiation, progression and metastasis.
Development Status and IP Strength
- PCT application filed