Daidzein and other Analogs as Agents for Purging HIV Reservoir
In the field of HIV research, proviral latency in specific long-lived cell types is the basis for the concept of one or more viral reservoirs, referring to locations (cell types or tissues) characterized by persistence of latent virus. Specifically, the presence of replication-competent HIV in resting CD4-positive T cells, allows this virus to persist for years without evolving despite prolonged exposure to antiretroviral drugs. This latent reservoir of HIV explains the inability of antiretroviral treatment to cure HIV infection.
Therapeutic Small Molecule Compounds