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Methods of Using Acyl-Coenzymea-Binding Proteins to Enhance Tolerance to Necrotrophic Fungal Pathogens in Genetically Modified Plants

Methods of Using Acyl-Coenzymea-Binding Proteins to Enhance Tolerance to Necrotrophic Fungal Pathogens in Genetically Modified Plants
Field
Transgenic Plants and Agriculture
Patent
IP00646

Key Problem and Market Opportunity

  • Fungal plant diseases are a significant concern in agriculture and food production worldwide.
  • Necrotrophic soil-borne pathogenic fungi such as Rhizoctonia and Fusarium infect major economically-important crops leading to severe yield loss.
  • World agriculture sustains average losses of around 16% annually as a result of fungal diseases.
  • To ensure a steady and uniform food supply to the rapidly mounting global population, there is an urgent need to control necrotrophic fungal diseases.
  • To this end, proteins that can protect plants from necrotrophic phytopathogens must be identified and subsequently tested for efficacy in transgenic crops.

Key Advantages of the Technology

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  • Acyl-CoA-binding protein (ACBP) are important house-keeping protein family that extends across eukaryotes and some prokaryotes.
  • Oryza sativa ACBP (OsACBP5) in plants improves tolerance to fungal necrotrophs
  • The present invention describes vectors/expression cassettes for conferring tolerance to fungal necrotrophs along with methods of using OsACBP5 to enhance tolerance to fungal necrotrophs and for screening for genes with OsACBP5-like activity.
  • The invention further describes plants and plant material with improved tolerance to fungal necrotrophs.

Potential Product and Services

  • Transgenic plants and plant material
  • Plant transformation vectors for improving tolerance to fungal necrotrophs in plants

Development Status and IP Strength

  • PCT application No. WO2018010075

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