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Technology Offerings (invention with patent)

An antibody for predicting Tamoxifen response in breast cancer patients

Tamoxifen, an antagonist of estrogen receptor (ER), is the most commonly used chemotherapeutic agent for the treatment of ER-positive breast cancer.

Molecular Diagnostics

Live-Attenuated Influenza Viruses of Vaccine

Live attenuated influenza vaccine (LAIV) is generally regarded to be superior to traditional inactivated vaccines for the noninvasive mean of administration and stimulation of stronger immune responses. Currently, the only FDA approved LAIV is FluMist. However, recent studies showed that FluMist is not very effective. In addition, the production cost is high since the vaccine needs to be produced in human cell lines.

Therapeutic Biological Agents

HC: A Novel Copolymer for Sustained Drug Delivery

Even though chitosan is a versatile compound for sustained drug delivery systems in formats like hydrogel, sponge and powder, being insoluble in water, hydrophilic in nature and the need of an acidic medium to be functional have greatly limited its applications

Medical Devices and New Materials

Daidzein and other Analogs as Agents for Purging HIV Reservoir

In the field of HIV research, proviral latency in specific long-lived cell types is the basis for the concept of one or more viral reservoirs, referring to locations (cell types or tissues) characterized by persistence of latent virus. Specifically, the presence of replication-competent HIV in resting CD4-positive T cells, allows this virus to persist for years without evolving despite prolonged exposure to antiretroviral drugs. This latent reservoir of HIV explains the inability of antiretroviral treatment to cure HIV infection.

Therapeutic Small Molecule Compounds

Materials And Methods For Filling Biological Cavities And Preventing Leakage Of Injected Therapeutic Agents

Injection of biomolecules, genes and cells is commonly used in biological therapies. For example, intra-discal injection of biomolecules such as transforming growth factor-beta 1 has been used in the treatment of degenerative intervertebral discs (IVD). Recently, mesenchymal stem cell (MSC)-based therapy for treating degenerative discs has received much attention.

Medical Devices and New Materials

Aptamers for the Treatment of Osteoporosis

Currently only 3 product classes available in the market. Among them, bisphonsphonate and SERMs are in the late growth phase of the product life cycle, while parathyroid hormones is in the infancy stage. All these drugs have severe side effects to the body.

Therapeutic Biological Agents

Anti-HER2 and Anti-IGF-IR Bi-specific Antibodies for Ovarian Cancers

IGF-1R is implicated in several cancers. Due to the similarity of the structures of IGF-1R and the insulin receptor (IR), especially in the regions of the ATP binding site and tyrosine kinase regions, synthesizing selective inhibitors of IGF-1R is difficult.

Therapeutic Biological Agents

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